Pathway collages: personalized multi-pathway diagrams
نویسندگان
چکیده
منابع مشابه
Bowtie Structures, Pathway Diagrams, and Topological Explanation
While mechanistic explanation and, to a lesser extent, nomological explanation are well-explored topics in the philosophy of biology, topological explanation is not. Nor is the role of diagrams in topological explanations. These explanations do not appeal to the operation of mechanisms or laws, and extant accounts of the role of diagrams in biological science explain neither why scientists migh...
متن کاملPathway-based personalized analysis of cancer.
We introduce Pathifier, an algorithm that infers pathway deregulation scores for each tumor sample on the basis of expression data. This score is determined, in a context-specific manner, for every particular dataset and type of cancer that is being investigated. The algorithm transforms gene-level information into pathway-level information, generating a compact and biologically relevant repres...
متن کاملMining and integration of pathway diagrams from imaging data
MOTIVATION Pathway diagrams from PubMed and World Wide Web (WWW) contain valuable highly curated information difficult to reach without tools specifically designed and customized for the biological semantics and high-content density of the images. There is currently no search engine or tool that can analyze pathway images, extract their pathway components (molecules, genes, proteins, organelles...
متن کاملDynamic exploration and editing of KEGG pathway diagrams
MOTIVATION The Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway database is a very valuable information resource for researchers in the fields of life sciences. It contains metabolic and regulatory processes in the form of wiring diagrams, which can be used for browsing and information retrieval as well as a base for modeling and simulation. Thus it helps in understanding biological proce...
متن کاملIndex Models for Pathway Based Personalized Prognostic Gene Expression Signatures
A main challenge of personalized medicine is to identify the individuating features of a patient and specify the way in which they can be used to determine an optimal treatment. Molecular profiling holds major promise to this end. Indeed, NIH Director Francis Collins suggests that the development of targeted therapeutics based on a molecular understanding of disease may be the “most profound co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2016
ISSN: 1471-2105
DOI: 10.1186/s12859-016-1382-1